- PII
- 10.31857/S0023476124020105-1
- DOI
- 10.31857/S0023476124020105
- Publication type
- Article
- Status
- Published
- Authors
- Volume/ Edition
- Volume 69 / Issue number 2
- Pages
- 268-276
- Abstract
- The oligomeric state of the nucleoid-associated protein IHF (integration host factor) plays a significant role in organizing and compacting bacterial nucleoids, as well as in the process of bacterial resistance to adverse environmental conditions, including antibiotics. Although IHF was identified more than 25 years ago, the molecular mechanisms of its involvement in such processes remain poorly understood. In this study, using small-angle X-ray scattering, various oligomeric forms of IHF were first identified in aqueous solution depending on the presence of metal cations. It was found that the presence of Mg2+ and K+ ions inhibits the formation of high-order oligomers. The obtained data can be useful in developing strategies to overcome bacterial resistance to drugs.
- Keywords
- Date of publication
- 15.09.2025
- Year of publication
- 2025
- Number of purchasers
- 0
- Views
- 14
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