- PII
- S3034551025060124-1
- DOI
- 10.7868/S3034551025060124
- Publication type
- Article
- Status
- Published
- Authors
- Volume/ Edition
- Volume 70 / Issue number 6
- Pages
- 976-983
- Abstract
- Rational vaccine design requires not only the prediction of immunogenic epitopes, but also a careful assessment of the structural stability of candidates and their ability to effectively interact with innate immunity receptors. The stability of four candidate vaccines and their complexes with toll-like receptors was assessed using molecular dynamics modeling using the Gromacs-2023 software package. The structures of the complexes of the considered chimeric candidate proteins for the Dengue virus vaccine with extracellular domains (ectodomains) of human toll-like receptors TLR4 and TLR8 were obtained as a result of molecular docking performed by the ZDOCK server. The affinity of the complexes was evaluated using the PRODIGY server.
- Keywords
- Date of publication
- 12.09.2025
- Year of publication
- 2025
- Number of purchasers
- 0
- Views
- 6
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