Investigation of subunit vaccine candidates against african swine fever vaccine candidates derived from subdomains of the transmembrane protein CD2v, using immunoinformatics and molecular dynamics metods

Occupation: Smart Materials Research Institute, Southern Federal University
Affiliation:
National Research Centre “Kurchatov Institute”
Southern Federal University

Y. V. Pisarevsky

Affiliation: National Research Centre “Kurchatov Institute”

Y. A. Dyakova

Affiliation: National Research Centre “Kurchatov Institute”

Volume/ Edition

Volume 70 / Issue number 3

Pages

506-510

Abstract

African swine fever (ASF) remains a global threat to pig production, causing economic losses. In this study, a theoretical comparison of candidate subunit vaccines based on the ASFV transmembrane protein CD2v was performed. Three supramembrane subdomains of CD2v were evaluated using immunoinformatics, structure prediction and molecular modeling methods. The results show that all candidates are non-toxic, non-allergenic and able to induce a stable immune response, including long-term antibody production. Subdomain A stands out as the most promising due to its high immunogenicity, despite potential difficulties in expression in Escherichia coli. Immunomodeling of activation of both primary and secondary immune responses, analysis of structural stability showed the reliability of the candidates under ascertaining conditions. The study provides a theoretical basis for further experimental development of subunit vaccines against ASF, combining safety and efficacy.

Keywords

Date of publication

01.03.2025

Year of publication

2025

Number of purchasers

Views

References

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GOST	Chernyavsky �., Dyakova Y., Ivanovsky �., Kordonskaya Y., Marchenkova �., Pisarevsky Y., Timofeev V., Tulenev �. Investigation of subunit vaccine candidates against african swine fever vaccine candidates derived from subdomains of the transmembrane protein CD2v, using immunoinformatics and molecular dynamics metods // Crystallography Reports. – 2025. – V. 70. – Issue number 3 C. 506-510 . URL: https://crystallographyras.ru/s30345510s0023476125030174-1/?version_id=119642. DOI: 10.7868/S3034551025030174
MLA	Chernyavsky, А. А, Dyakova, Y. A, Ivanovsky, А. S, Kordonskaya, Y. V, Marchenkova, М. А, Pisarevsky, Y. V, Timofeev, V. I, Tulenev, А. А "Investigation of subunit vaccine candidates against african swine fever vaccine candidates derived from subdomains of the transmembrane protein CD2v, using immunoinformatics and molecular dynamics metods." Crystallography Reports. 70.3 (2025).:506-510. DOI: 10.7868/S3034551025030174
APA	Chernyavsky �., Dyakova Y., Ivanovsky �., Kordonskaya Y., Marchenkova �., Pisarevsky Y., Timofeev V., Tulenev �. (2025). Investigation of subunit vaccine candidates against african swine fever vaccine candidates derived from subdomains of the transmembrane protein CD2v, using immunoinformatics and molecular dynamics metods. Crystallography Reports. vol. 70, no. 3, pp.506-510 DOI: 10.7868/S3034551025030174

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Investigation of subunit vaccine candidates against african swine fever vaccine candidates derived from subdomains of the transmembrane protein CD2v, using immunoinformatics and molecular dynamics metods

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Investigation of subunit vaccine candidates against african swine fever vaccine candidates derived from subdomains of the transmembrane protein CD2v, using immunoinformatics and molecular dynamics metods

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